QUOTE(RositaK @ 2013 08 07, 16:04)
perskaiciau 
nu bet neraso, kad ZP parodo embriono implantavimosi problemas kaip kad rasei
nu bet neraso, kad ZP parodo embriono implantavimosi problemas kaip kad rasei
Jo, nerašo, ką aš žinau, man Adas taip aiškino. Liepė visus pasidaryt ir būtent šitą man įtarė, sakė, tai svarbu pirmomis dienomis po įsodinimo. Tiek ir žinau
Papildyta:
Gal jis ne visai tiksliai išsireiškė ar gal ne visai tiksliai viską žino, nu bet principas panašus:
Using an indirect immunofluorescence assay with porcine ova, 11 of 69 (15.9%) women with infertility and 13
of 46 (28.3%) women with recurrent spontaneous abortion of
undetermined etiology had anti-zona pellucida antibody
titers of 1:4 or greater. In contrast, none of 56 control
individuals had positive anti-zona pellucida titers.
Forty-two infertility patients undergoing ro
fertilization were fertilized for levels of circulating
anti-zona pellucida antibodies. Six of 42 patients
(14.3%) had circulating antibody titers of 1:4 or greater.
In 16 of these patients, paired serum and follicular fluid
antibody titers were compared. Of these, five had positive serum titers (1:4 or greater). Of these five, four
were found to also have antibody in the follicular fluid
at a titer of 1:2 or greater. Of the remaining 11 samples
that were negative for serum antibody, 5 of the corresponding follicular fluids were also negative and 6 were
positive at undiluted only. These results demonstrate
that antibodies against the zona pellucida can pass from
the serum into the follicular fluid, and suggest that
there is a relationship between the presence of serum and
intrafollicular autoantibodies against the zona pellucida.
Antibodies produced against the zona pellucida (ZP)
of mammalian eggs have been implicated as a cause of
reproductive failure by either prevention of fertilization
or inhibition of implantation of the ovum.
Papildyta:
We, therefore, investigated the relationship between serum titers
and the success of in vitro fertilization. Those patients
with lower serum titers (1:4) were found to be treatable
by __ fertilization, while the patient with the
highest serum titer (1:16) and a follicular fluid titer of
1:4 was not fertilizable by her husband's or unrelated
donor's sperm. Although the small sample size limits the
interpretation of this observation, it may suggest that
low anti-zona pellucida titers can be successfully treated
by fertilization, whereas higher titers cannot.
This may be due to the washing procedures that are
utilized during the IVF procedure before the oocytes are
incubated with sperm. Such rinsing may be able to remove
enough antibody to allow sperm attachment and penetration.
The actual removal of the oocyte from the antibody containing follicular fluid may also decrease the amount of
antibody coating the oocyte at the time of fertilization.
At this time it is not possible to determine whether IgG
is still present on the surface of the ovum at the time of
the IVF procedure. Although the oocytes from patients with low titers of antibody were successfully fertilized
with this procedure, there is still the potential that
anti-zona pellucida antibody may prevent implantation,
since none of these women became pregnant. A much larger
patient population in addition to a greater percentage of
successful implantations and pregnancies is needed before
it can be determined whether anti-zona pellucida antibodies can interfere with the implantation step of the IVF
procedure.
In summary, we have observed that circulating antizona pellucida antibodies are specifically associated with
infertility and spontaneous recurrent abortion of unexplained etiology. These antibodies can also be found in
follicular fluid. Infertility in conjunction with low
titers of anti-zona pellucida antibody is treatable by in
vitro fertilization, but higher titers of antibody may
preclude successful treatment.
